Pharmacology & Toxicology

1.Senna-containing laxatives: excretion in the breast milk? Faber P; Strenge-Hesse A, Geburtshilfe Frauenheilkd 1989 Nov;49(11):958-6


2.Two-year carcinogenicity study with sennosides in the rat: emphasis on gastro-intestinal alterations. Lyd’en-Sokolowski A; Nilsson A; Sioberrg P, Pharmacology; VOL 47 Suppl 1, 1993, P209-15


3. Acute hemorrhagic colitis following administration of sennosides A and B (letter), Villand J, Presse Med, 14(2):104-5 1985 Jan 19


4. Influence of a highly purified senna extract on colonic epithelium. van Gorkom BA; Karrenbeld A; van Der Sluis T;  Koudstaal J; de Vries EG; Kleibeuker JH, Digestion, 61(2):113-20 2000


5. Analytics of senna drugs with regard to the toxicological discussion of anthranoids., Grimminger W; Witthohn K, Pharmacology, 47 Suppl 1(-HD-):98-109 1993 Oct


6. Genotoxicity of sennosides on the bone marrow cells of mice. Mukhopadhyay MJ; Saha A; Dutta A; De B;Mukherjee A, Food Chem Toxicol 36(11):937-40 1998 Nov


7. Sennosides and human colonic motility. Staumont G; Frexinos J; Fioramonti J; Bu’eno L Pharmacology, 36 Suppl 1 (-HD-):49-56 1988


8. Long-term mucosal alterations by sennosides and related compounds. Dufour P; Gendre P Pharmacology 36 Suppl 1(-HD-):194-202 1988


9. Laxative potency and acute toxicity of some anthraquinone derivatives, senna extracts and fractions of senna extracts. Hietala P; Marvola M; Parviainen T; Laininen H, Pharmacol Toxicol, 61(2):153-6 1987 Aug


10. Toxic effects of sennosides in laboratory animals and in vitro. Mengs U, Pharmacology, 36 Suppl 1(-HD-):180-7 1988


11. Review article: anthranoid laxatives and their potential carcinogenic effects. van Gorkom BA ; de Vries EG ; Karrenbeld A ; Kleibeuker JH, Aliment Pharmacol Ther, 13(4):443-52 1999 Apr

12. Measurement of the intestinal clearance of alpha 1-antitrypsin and the exchangeable potassium pool in elderly patients treated with anthraquinone glycosides. Emeriau JP ; Manciet G ; Borde C ; Raynal F ; Galley P, Gastroenterol Clin Biol; VOL 7, ISS 10, 1983, P799-801


13. Two-year carcinogenicity study with sennosides in the rat: emphasis on gastro-intestinal alterations. Lyd´en-Sokolowski A ; Nilsson A ; Sj¨oberg P, Pharmacology, 47 Suppl 1(-HD-)  :209-15 1993 Oct


14. Ultrastructure of mouse intestinal mucosa and changes observed after long term anthraquinone administration. Dufour P ; Gendre P, Gut; VOL 25, ISS 12, 1984, P1358-63


15. The genotoxicity status of senna. Heidemann A ; Miltenburger HG ; Mengs U, Pharmacology, 47 Suppl 1(-HD-)
:178-86 1993 Oct


16. Effects of ‘contact laxatives’ on intestinal and colonic epithelial cell proliferation. Geboes K ; Nijs G ; Mengs U ; Geboes KP ; Van Damme A ; de Witte P, Pharmacology, 47 Suppl 1(-HD-):187-95 1993 Oct


17. Effect of sennosides and related compounds on intestinal transit in the rat. Leng-Peschlow E, Pharmacology, 36 Suppl 1(-HD-):40-8 1988



18. Reproductive toxicological investigations with sennosides. Mengs U, Arzneimittelforschung, 36(9):1355-8 1986 Sep


19. Effect of sennosides on colon motility in dogs. Fioramonti J ; Staumont G ; Garcia-Villar R ; Bu´eno L, Pharmacology, 36 Suppl 1(-HD-):23-30 1988


20. Effects of sennosides on colonic myoelectrical activity in man. Frexinos J ; Staumont G ; Fioramonti J ; Bueno L, Dig Dis Sci, 34(2):214-9 1989 Feb


21. Effects of long-term sennoside treatment on in vitro motility of rat colon. Odenthal KP ; Leng-Peschlow E ; Voderholzer W ; M¨uller-Lissner S, Pharmacology, 47 Suppl 1(-HD-):146-54 1993 Oct

22. Chronic sennoside treatment does not cause habituation and secondary hyperaldosteronism in rats. Leng-Peschlow E ; Odenthal KP ; Voderholzer W ; M¨uller-Lissner S, Pharmacology, 47 Suppl 1(-HD-):162-71 1993 Oct


23. Evaluation of the potential carcinogenic activity of Senna and Cascara glycosides for the rat colon. Mereto E ; Ghia M ; Brambilla G, Cancer Lett, 101(1):79-83 1996 Mar 19



Historical or
traditional use
Chemistry, Isolation
and Constituents
Nutritional Profile Mechanism of Action
Pharmacology &
Manufacture of
Calcium Sennosides
Quality Control Method of Analysis of Assay
Analytical Methods .

(manufacturers of Sennoside, Calcium Sennoside, Senna Extract)